La Sociedad Española de Medicina Interna (SEMI) ha desarrollado un registro online que incluye un número extenso de parámetros epidemiológicos, clínicos, de tratamiento, de laboratorio y radiográficos, que se obtendrán de las historias clínicas electrónicas de los pacientes hospitalizados con infección por SARS-CoV-2 confirmada por laboratorio de los hospitales españoles. El estudio ha sido clasificado como observacional no-EPA por la AEMPS y ha sido autorizado por el CEI Provincial de Málaga. La aplicación del registro está en: https://covid.reginus.es

A fecha 29 de noviembre de 2021, gracias a la colaboración de más de 700 investigadores de la Sociedad Española de Medicina Interna, se han incluido en el Registro más de 25.000 pacientes.

Publicaciones derivadas del Registro hasta el momento:

Originales:​

1. Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, Gómez-Huelgas R, Ramos-Rincón JM, Rubio-Rivas M, Corrales-González MÁ, Fernández-Madera-Martínez MR, Beato-Pérez JL, Arnalich-Fernández F, Gállego-Lezaun C, Pérez-Martínez P, Molinos-Castro S, Tung-Chen Y, Madrazo M, Méndez-Bailón M, Monge-Monge D, García-García GM, García-Fenoll R, Gilabert N, Fuerte-Martínez R, Contreras-Sánchez M, Rhyman N, Peris-García J, Lumbreras-Bermejo C, The SEMI-COVID-19 Network. Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry. Sci Rep. 2023;13(1):17731. doi:10.1038/s41598-023-42735-5
2. Klén R, Huespe IA, Gregalio FA, Lalueza Blanco AL, Pedrera Jimenez M, Garcia Barrio N, Valdez PR, Mirofsky MA, Boietti B, Gómez-Huelgas R, Casas-Rojo JM, Antón-Santos JM, Pollan JA, Gómez-Varela D. Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: a multicontinental retrospective study. eLife. 2023;12:e85618. doi:10.7554/eLife.85618
3. Casas-Rojo JM, Ventura PS, Antón Santos JM, De Latierro AO, Arévalo-Lorido JC, Mauri M, Rubio-Rivas M, González-Vega R, Giner-Galvañ V, Otero Perpiñá B, Fonseca-Aizpuru E, Muiño A, Del Corral-Beamonte E, Gómez-Huelgas R, Arnalich-Fernández F, Llorente Barrio M, Sancha-Lloret A, Rábago Lorite I, Loureiro-Amigo J, Pintos-Martínez S, García-Sardón E, Montaño-Martínez A, Rojano-Rivero MG, Ramos-Rincón JM, López-Escobar A, On behalf of the SEMI-COVID-19 Network. Improving prediction of COVID-19 mortality using machine learning in the Spanish SEMI-COVID-19 registry. Intern Emerg Med. Published online June 22, 2023. doi:10.1007/s11739-023-03338-0
4. Gómez-Antúnez M, Muiño-Míguez A, Bacete-Cebrián M, Rubio-Rivas M, de Cossío S, Peris-García J, López-Caleya JF, García-García GM, Casas-Rojo JM, Núñez-Cortés JM. Patients with COPD hospitalized due to COVID-19 in Spain: A comparison between the first and second wave. Revista Clínica Española (English Edition). Published online April 5, 2023. doi:10.1016/j.rceng.2023.04.002
5. Maestro de la Calle G, García Reyne A, Lora-Tamayo J, Muiño Miguez A, Arnalich-Fernandez F, Beato Pérez JL, Vargas Núñez JA, Caudevilla Martínez MA, Alcalá Rivera N, Orviz Garcia E, Sánchez Moreno B, Freire Castro SJ, Rhyman N, Pesqueira Fontan PM, Piles L, López Caleya JF, Fraile Villarejo ME, Jiménez-García N, Boixeda R, González Noya A, Gracia Gutiérrez A, Martín Oterino JÁ, Gómez Huelgas R, Antón Santos JM, Lumbreras Bermejo C, SEMI-COVID-19 Network. Impact of days elapsed from the onset of symptoms to hospitalization in COVID-19 in-hospital mortality: time matters. Rev Clin Esp (Barc). Published online March 28, 2023:S2254-8874(23)00045-0. doi:10.1016/j.rceng.2023.03.006
6. Martínez-López J, De La Cruz J, Gil-Manso R, Alegre A, Ortiz J, Llamas P, Martínez Y, Hernández-Rivas JÁ, González-Gascón I, Benavente C, Estival Monteliu P, Jiménez-Yuste V, Canales M, Bastos M, Kwon M, Valenciano S, Callejas-Charavia M, López-Jiménez J, Herrera P, Duarte R, Núñez Martín-Buitrago L, Sanchez Godoy P, Jacome Yerovi C, Martínez-Barranco P, García Roa M, Escolano Escobar C, Matilla A, Rosado Sierra B, Aláez-Usón MC, Quiroz-Cervantes K, Martínez-Chamorro C, Pérez-Oteyza J, Martos-Martinez R, Herráez R, González-Santillana C, Del Campo JF, Alonso A, De La Fuente A, Pascual A, Bustelos-Rodriguez R, Sebrango A, Ruiz E, Marcheco-Pupo EA, Grande C, Cedillo Á, Lumbreras C, Arroyo Barea A, Casas-Rojo JM, Calbacho M, Diez-Martín JL, García-Suárez J. COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study. Cancers. 2023;15(5):1497. doi:10.3390/cancers15051497
7. Ramos-Rincón JM, Ventura PS, Casas-Rojo JM, Mauri M, Bermejo CL, de Latierro AO, Rubio-Rivas M, Mérida-Rodrigo L, Pérez-Casado L, Barrientos-Guerrero M, Giner-Galvañ V, Gallego-Lezaun C, Milián AH, Manzano L, Blázquez-Encinar JC, Solís-Marquínez MN, García MG, Lobo-García J, Valente VAR, Roig-Martí C, León-Téllez M, Tellería-Gómez P, González-Juárez MJ, Gómez-Huelgas R, López-Escobar A, SEMI-COVID-19 Network. Validation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry. Intern Emerg Med. Published online January 21, 2023:1-9. doi:10.1007/s11739-023-03200-3
8. Ramos-Rincon JM, Lopez-Sampalo A, Cobos-Palacios L, Ricci M, Rubio-Rivas M, Díaz-Simón R, Martín-Escalante MD, Castañeda-Pérez S, Fernández-Madera-Martínez R, Beato-Perez JL, García-García GM, García-Andreu MDM, Arnalich-Fernandez F, Molinos-Castro S, Vargas-Núñez JA, Artero A, Freire-Castro SJ, Fernández-Gómez J, Cubo-Romano P, Hernández-Milián A, Inés-Revuelta SM, Boixeda R, Fernández-Pedregal E, Gómez-Huelgas R, SEMI-COVID-19 Network. Nosocomial COVID-19: A Nationwide Spanish Study. Gerontology. Published online January 20, 2023:1-13. doi:10.1159/000527711
9. Huespe IA, Ferraris A, Lalueza A, Valdez PR, Peroni ML, Cayetti LA, Mirofsky MA, Boietti B, Gómez-Huelgas R, Casas-Rojo JM, Antón-Santos JM, Núñez-Cortés JM, Lumbreras C, Ramos-Rincón JM, Barrio NG, Pedrera-Jiménez M, Martin-Escalante MD, Ruiz FR, Onieva-García MÁ, Toso CR, Risk MR, Klén R, Pollán JA, Gómez-Varela D. COVID-19 vaccines reduce mortality in hospitalized patients with oxygen requirements: Differences between vaccine subtypes. A multicontinental cohort study. Journal of Medical Virology. 2023;95(5):e28786. doi:10.1002/jmv.28786
10. Ramos-Rincon JM, Cobos-Palacios L, López-Sampalo A, Ricci M, Rubio-Rivas M, Nuñez-Rodriguez MV, Miranda-Godoy R, García-Leoni ME, Fernández-Madera-Martínez R, García-García GM, Beato-Perez JL, Monge-Monge D, Asín-Samper U, Bustamante-Vega M, Rábago-Lorite I, Freire-Castro SJ, Miramontes-González JP, Magallanes-Gamboa JO, Alcalá-Pedrajas JN, García-Gómez M, Cano-Llorente V, Carrasco-Sánchez FJ, Martinez-Carrilero J, Antón-Santos JM, Gómez-Huelgas R, SEMI-COVID-19 Network. Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain). BMC Geriatr. 2022;22(1):546. doi:10.1186/s12877-022-03191-4
11. Giner-Galvañ V, Pomares-Gómez F, Quesada J, Rubio-Rivas M, Tejada-Montes J, Baltasar-Corral J, Taboada-Martínez M, Sánchez-Mesa B, Arnalich-Fernández F, Del Corral-Beamonte E, López-Sampalo A, Pesqueira-Fontán P, Fernández-Garcés M, Gómez-Huelgas R, Ramos-Rincón J, on behalf of the SEMI-COVID-19 Network. C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19. Biomedicines. 2022;10(6):1393. doi:10.3390/biomedicines10061393
12. Rubio-Rivas M, Mora-Luján JM, Formiga F, Corrales González MÁ, García Andreu MDM, Moreno-Torres V, García García GM, Alcalá Pedrajas JN, Boixeda R, Pérez-Lluna L, Cortés-Rodríguez B, Mella-Pérez C, Navas Alcántara M de la S, López Reboiro ML, Alfaro-Lara V, Pérez-Martín S, Martín-Oterino JÁ, Gracia Gutiérrez A, Martín-Urda Díez-Canseco A, Comas Casanova P, Pérez García C, Varona JF, Gómez-Huelgas R, Antón-Santos JM, Lumbreras-Bermejo C, SEMI-COVID-19 Network. Clusters of inflammation in COVID-19: descriptive analysis and prognosis on more than 15,000 patients from the Spanish SEMI-COVID-19 Registry. Intern Emerg Med. 2022;17(4):1115-1127. doi:10.1007/s11739-021-02924-4
13. Klén R, Purohit D, Gómez-Huelgas R, Casas-Rojo JM, Antón-Santos JM, Núñez-Cortés JM, Lumbreras C, Ramos-Rincón JM, García Barrio N, Pedrera-Jiménez M, Lalueza Blanco A, Martin-Escalante MD, Rivas-Ruiz F, Onieva-García MÁ, Young P, Ramirez JI, Titto Omonte EE, Gross Artega R, Canales Beltrán MT, Valdez PR, Pugliese F, Castagna R, Huespe IA, Boietti B, Pollan JA, Funke N, Leiding B, Gómez-Varela D. Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study. Elife. 2022;11:e75985. doi:10.7554/eLife.75985
14. Rubio-Rivas M, Mora-Luján JM, Formiga F, Arévalo-Cañas C, Lebrón Ramos JM, Villalba García MV, Fonseca Aizpuru EM, Díez-Manglano J, Arnalich Fernández F, Romero Cabrera JL, García García GM, Pesqueira Fontan PM, Vargas Núñez JA, Freire Castro SJ, Loureiro Amigo J, Pascual Pérez M de los R, Alcalá Pedrajas JN, Encinas-Sánchez D, Mella Pérez C, Ena J, Gracia Gutiérrez A, Esteban Giner MJ, Varona JF, Millán Núñez-Cortés J, Casas-Rojo JM. WHO Ordinal Scale and Inflammation Risk Categories in COVID-19. Comparative Study of the Severity Scales. J GEN INTERN MED. Published online April 8, 2022:1-8. doi:10.1007/s11606-022-07511-7
15. Olalla-Sierra J, Martín-Escalante MD, García-Alegría J, Rubio-Rivas M, de Miguel-Campo B, Zurita-Etayo M, Arbones-Fernández L, Alcalá-Pedrajas JN, Roldán-Silvestre A, Cortés-Rodríguez B, Casas-Rojo JM, Núñez-Cortés JM, SEMI-COVID-19 Network. Coronavirus disease 2019 hospitalization outcomes in persons with and without HIV in Spain. AIDS. 2022;36(5):683-690. doi:10.1097/QAD.0000000000003056
16. Arévalo-Lorido JC, Carretero-Gómez J, Casas-Rojo JM, Antón-Santos JM, Melero-Bermejo JA, López-Carmona MD, Palacios LC, Sanz-Cánovas J, Pesqueira-Fontán PM, de la Peña-Fernández AA, de la Sierra Alcántara NM, García-García GM, Torres Peña JD, Magallanes-Gamboa JO, Fernández-Madera-Martinez R, Fernández-Fernández J, Rubio-Rivas M, Maestro-de la Calle G, Cervilla-Muñoz E, Ramos-Martínez A, Méndez-Bailón M, Ramos-Rincón JM, Gómez-Huelgas R, SEMI-COVID-19 Network. The importance of association of comorbidities on COVID-19 outcomes: a machine learning approach. Curr Med Res Opin. 2022;38(4):501-510. doi:10.1080/03007995.2022.2029382
17. Calderón-Parra J, Cuervas-Mons V, Moreno-Torres V, Rubio-Rivas M, Blas PA de, Pinilla-Llorente B, Helguera-Amezua C, Jiménez-García N, Pesqueira-Fontan PM, Méndez-Bailón M, Artero A, Gilabert N, Ibánez-Estéllez F, Freire-Castro SJ, Lumbreras-Bermejo C, Antón-Santos JM. Influence of chronic use of corticosteroids and calcineurin inhibitors on COVID-19 clinical outcomes: analysis of a nationwide registry. International Journal of Infectious Diseases. 2022;116:51-58. doi:10.1016/j.ijid.2021.12.327
18. Azaña Gómez J, Pérez-Belmonte LM, Rubio-Rivas M, Bascuñana J, Quirós-López R, Taboada Martínez ML, Montero Hernandez E, Roque-Rojas F, Méndez-Bailón M, Gómez-Huelgas R. Factores de riesgo de mortalidad en pacientes con infección por SARS-CoV-2 y fibrilación auricular: datos del registro SEMI-COVID-19. Medicina Clínica. Published online March 2022:S0025775322000549. doi:10.1016/j.medcli.2022.01.008
19. Ramos-Rincon JM, Cobos-Palacios L, López-Sampalo A, Ricci M, Rubio-Rivas M, Martos-Pérez F, Lalueza-Blanco A, Moragón-Ledesma S, Fonseca-Aizpuru EM, García-García GM, Beato-Perez JL, Josa-Laorden C, Arnalich-Fernández F, Molinos-Castro S, Torres-Peña JD, Artero A, Vargas-Núñez JA, Mendez-Bailon M, Loureiro-Amigo J, Hernández-Garrido MS, Peris-García J, López-Reboiro ML, Barón-Franco B, Casas-Rojo JM, Gómez-Huelgas R, on behalf of the SEMI-COVID-19 Network. Ethnicity and Clinical Outcomes in Patients Hospitalized for COVID-19 in Spain: Results from the Multicenter SEMI-COVID-19 Registry. Journal of Clinical Medicine. 2022;11(7):1949. doi:10.3390/jcm11071949
20. Fernández-Cruz A, Puyuelo A, Núñez Martín-Buitrago L, Sánchez-Chica E, Díaz-Pedroche C, Ayala R, Lizasoain M, Duarte R, Lumbreras C, Antonio Vargas J. Higher mortality of hospitalized haematologic patients with COVID-19 compared to non-haematologic is driven by thrombotic complications and development of ARDS: An age-matched cohorts study. Clin Infect Pract. 2022;13:100137. doi:10.1016/j.clinpr.2022.100137
21. Lavilla Olleros C, Ausín García C, Bendala Estrada AD, Muñoz A, Wikman Jogersen PE, Fernández Cruz A, Giner Galvañ V, Vargas JA, Seguí Ripoll JM, Rubio-Rivas M, Miranda Godoy R, Mérida Rodrigo L, Fonseca Aizpuru E, Arnalich Fernández F, Artero A, Loureiro Amigo J, García García GM, Corral Gudino L, Jiménez Torres J, Casas-Rojo JM, Millán Núñez-Cortés J, SEMI-COVID-19 Network. Use of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19. PLoS One. 2022;17(1):e0261711. doi:10.1371/journal.pone.0261711
22. Carrasco-Sánchez FJ, López-Carmona MD, Martínez-Marcos FJ, Pérez-Belmonte LM, Hidalgo-Jiménez A, Buonaiuto V, Suárez Fernández C, Freire Castro SJ, Luordo D, Pesqueira Fontan PM, Blázquez Encinar JC, Magallanes Gamboa JO, de la Peña Fernández A, Torres Peña JD, Fernández Solà J, Napal Lecumberri JJ, Amorós Martínez F, Guisado Espartero ME, Jorge Ripper C, Gómez Méndez R, Vicente López N, Román Bernal B, Rojano Rivero MG, Ramos Rincón JM, Gómez Huelgas R. Admission hyperglycaemia as a predictor of mortality in patients hospitalized with  COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19  Registry. Ann Med. 2021;53(1):103-116. doi:10.1080/07853890.2020.1836566
23. Formiga F, Rubio-Rivas M, Mora-Luján JM, Escudero SC, Martinez RFM, Mendez-Bailón M, Campo PD del, Pérez AR, García-Sánchez FJ, Alcalá-Pedrajas JN, Hernández SA, Milian AH, Díez AL, Sánchez RG, Boixeda R, Vicente J, Cortes B, Pérez CM, Espartero MEG, Castro JL, Suárez SR, Varona JF, Gomez-Huelgas R, Ramos-Rincón JM. Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry. Intern Emerg Med. Published online November 29, 2021:1-15. doi:10.1007/s11739-021-02870-1
24. Bendala Estrada AD, Calderón Parra J, Fernández Carracedo E, Muiño Míguez A, Ramos Martínez A, Muñez Rubio E, Rubio-Rivas M, Agudo P, Arnalich Fernández F, Estrada Perez V, Taboada Martínez ML, Crestelo Vieitez A, Pesqueira Fontan PM, Bustamante M, Freire SJ, Oriol-Bermúdez I, Artero A, Olalla Sierra J, Areses Manrique M, Carrasco-Sánchez HFJ, Vento VC, García García GM, Cubero-Morais P, Casas-Rojo JM, Núñez-Cortés JM. Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy. BMC Infect Dis. 2021;21(1):1144. doi:10.1186/s12879-021-06821-1
25. Navas Alcántara MS, Montero Rivas L, Guisado Espartero ME, Rubio-Rivas M, Ayuso García B, Moreno Martinez F, Ausín García C, Taboada Martínez ML, Arnalich Fernández F, Martínez Murgui R, Molinos Castro S, Ramos Muñoz ME, Fernández-Garcés M, Carreño Hernandez MC, García García GM, Vázquez Piqueras N, Abadía-Otero J, Lajara Villar L, Salazar Monteiro C, Pascual Pérez M de los R, Perez-Martin S, Collado-Aliaga J, Antón-Santos JM, Lumbreras-Bermejo C. Influencia de la historia de tabaquismo en la evolución de la hospitalización en pacientes COVID-19 positivos: datos del registro SEMI-COVID-19. Medicina Clínica. Published online November 2021:S0025775321006503. doi:10.1016/j.medcli.2021.10.011
26. Rubio-Rivas M, Mora-Luján JM, Montero A, Aguilar García JA, Méndez Bailón M, Fernández Cruz A, Oriol I, Teigell-Muñoz FJ, Dendariena Borque B, De la Peña Fernández A, Fernández González R, Gil Sánchez R, Fernández Fernández J, Catalán M, Cortés-Rodríguez B, Mella Pérez C, Montero Rivas L, Suárez Fuentetaja R, Ternero Vega JE, Ena J, Martin-Urda Díez-Canseco A, Pérez García C, Varona JF, Casas-Rojo JM, Millán Núñez-Cortés J, SEMI-COVID-19 Network. The Use of Corticosteroids or Tocilizumab in COVID-19 Based on Inflammatory Markers. J Gen Intern Med. Published online October 18, 2021. doi:10.1007/s11606-021-07146-0
27. Muñoz-Gómez A, Fernández-Cruz A, Lavilla-Olleros C, Giner-Galvañ V, Ausín-García C, Wikman P, Bendala-Estrada AD, Vargas JA, Rubio-Rivas M, Laureiro J, Fernández-Bermúdez D, Buonaiuto VA, Arenas de Larriva AP, Pascual-Pérez M de LR, Alcalá-Pedrajas JN, Labirua-Iturburu Ruiz A, Hernández-Milián A, Gómez Del Mazo M, Antequera B, Mella-Pérez C, Navas-Alcántara M de la S, Soto-Delgado JF, Gámez-Mancera RM, Sardiña-González C, Meijide-Míguez H, Ramos-Rincón JM, Gómez-Huelgas R, On Behalf Of The Semi-Covid-Network  null. Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study. J Clin Med. 2021;10(20):4678. doi:10.3390/jcm10204678
28. Ramos-Rincón JM, Bernabeu-Whittel M, Fiteni-Mera I, López-Sampalo A, López-Ríos C, García-Andreu MDM, Mancebo-Sevilla JJ, Jiménez-Juan C, Matía-Sanz M, López-Quirantes P, Rubio-Rivas M, Paredes-Ruiz D, González-San-Narciso C, González-Vega R, Sanz-Espinosa P, Hernández-Milián A, Gonzalez-Noya A, Gil-Sánchez R, Boixeda R, Alcalá-Pedrajas JN, Palop-Cervera M, Cortés-Rodríguez B, Guisado-Espartero ME, Mella-Pérez C, Gómez-Huelgas R, SEMI-COVID-19 Network. Clinical features and risk factors for mortality among long-term care facility residents hospitalized due to COVID-19 in Spain. J Gerontol A Biol Sci Med Sci. Published online October 9, 2021:glab305. doi:10.1093/gerona/glab305
29. Díaz-Simón R, Lalueza A, Lora-Tamayo J, Rubio-Rivas M, Mendo CL, Martínez MLT, Méndez CA, Pesqueira Fontán PM, Cruz AF, Cabrera JLR, Rodríguez BC, Rubio AE, de Ávila VSR, García GMG, Osorio LC, González-Fernández M, Noya AG, Wittel MB, Fernandez FA, Sempere VM, Artero A, Loureiro-Amigo J, Huelgas RG, Santos JMA, Lumbreras C. Clinical Characteristics and Risk Factors of Respiratory Failure in a Cohort of Young Patients Requiring Hospital Admission with SARS-CoV2 Infection in Spain:  Results of the Multicenter SEMI-COVID-19 Registry. J Gen Intern Med. Published online August 11, 2021:1-8. doi:10.1007/s11606-021-07066-z
30. Suárez-García I, Perales-Fraile I, González-García A, Muñoz-Blanco A, Manzano L, Fabregate M, Díez-Manglano J, Aizpuru EF, Fernández FA, García AG, Gómez-Huelgas R, Ramos-Rincón JM, Network  on behalf of SC 19. In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. PLOS ONE. 2021;16(8):e0255524. doi:10.1371/journal.pone.0255524
31. García-Cervera C, Giner-Galvañ V, Wikman-Jorgensen P, Laureiro J, Rubio-Rivas M, Gurjian Arena A, Arnalich-Fernandez F, Beato Pérez JL, Vargas Núñez JA, González Igual JJ, Díez-Manglano J, Méndez Bailón M, García Blanco MJ, Freire Castro SJ, Aranda Lobo J, Manzano L, Magallanes Gamboa JO, Arribas Pérez L, González Moraleja J, Calderón Hernaiz R, García Alegría J, González Noya A, Gómez Huelgas R, Lumbreras Bermejo C, Antón Santos JM. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry. J Gen Intern Med. Published online July 21, 2021:1-9. doi:10.1007/s11606-021-07017-8
32. Salinas-Botrán A, Sanz-Cánovas J, Pérez-Somarriba J, Pérez-Belmonte LM, Cobos-Palacios L, Rubio-Rivas M, de Cossío Tejido S, Manuel Ramos-Rincón J, Méndez-Bailón M, Gómez-Huelgas R. [Clinical characteristics and risk factors for mortality upon admission in patients with heart failure hospitalized due to COVID-19 in Spain]. Rev Clin Esp. Published online July 17, 2021. doi:10.1016/j.rce.2021.06.004
33. Martinez-Lacalzada M, Viteri-Noël A, Manzano L, Fabregate M, Rubio-Rivas M, Garcia SL, Fernández FA, Beato Pérez JL, Vargas Núñez JA, Manuel EC, Espiño Álvarez AC, Freire Castro SJ, Loureiro-Amigo J, Pesqueira Fontan PM, Pina A, Álvarez Suárez AM, Asiain AS, López BG, Luque Del Pino J, Cánovas JS, Pérez PC, García García GM, Núñez-Cortés JM, Casas Rojo JM, Huelgas RG. Predicting critical illness on initial diagnosis of COVID-19 based on easily-obtained clinical variables: development and validation of the PRIORITY  model. Clin Microbiol Infect. Published online July 15, 2021. doi:10.1016/j.cmi.2021.07.006
34. Ramos-Martínez A, Parra-Ramírez LM, Morrás I, Carnevali M, Jiménez-Ibañez L, Rubio-Rivas M, Arnalich F, Beato JL, Monge D, Asín U, Suárez C, Freire SJ, Méndez-Bailón M, Perales I, Loureiro-Amigo J, Gómez-Belda AB, Pesqueira PM, Gómez-Huelgas R, Mella C, Díez-García LF, Fernández-Sola J, González-Ferrer R, Aroza M, Antón-Santos JM, Bermejo CL. Frequency, risk factors, and outcomes of hospital readmissions of COVID-19 patients. Sci Rep. 2021;11(1):13733. doi:10.1038/s41598-021-93076-0
35. Ena J, Vicente Segura-Heras J, Fonseca-Aizpuru EM, López-Reboiro ML, Gracia-Gutiérrez A, Ángel Martín-Oterino J, Diez-Canseco AMU, Pérez-García C, Manuel Ramos-Rincón J, Gómez-Huelgas R, en nombre del grupo de trabajo SEMI-COVID-19. [Derivation and validation of a risk score for admission to the intensive care unit in patients with COVID-19]. Rev Clin Esp. Published online June 23, 2021. doi:10.1016/j.rce.2021.06.003
36. Calderón-Parra J, Muiño-Miguez A, Bendala-Estrada AD, Ramos-Martínez A, Muñez-Rubio E, Carracedo EF, Montes JT, Rubio-Rivas M, Arnalich-Fernandez F, Pérez JLB, Bruñén JMG, Beamonte E del C, Fontan PMP, Carmona M del M, Martínez RFM, García AG, Mosteiro CS, Almeida CT de, Moraleja JG, Deodati F, Escalante MDM, Tomás MLA, Huelgas RG, Rojo JMC, Núñez-Cortés JM, Network  for the SC 19. Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID. PLOS ONE. 2021;16(5):e0251340. doi:10.1371/journal.pone.0251340
37. Ramos-Rincón JM, Pérez-Belmonte LM, Carrasco-Sánchez FJ, Jansen-Chaparro S, De-Sousa-Baena M, Bueno-Fonseca J, Pérez-Aguilar M, Arévalo-Cañas C, Bacete Cebrian M, Méndez-Bailón M, Fiteni Mera I, González García A, Navarro Romero F, Tuñón de Almeida C, Muñiz Nicolás G, González Noya A, Hernández Milian A, García García GM, Alcalá Pedrajas JN, Herrero García V, Corral-Gudino L, Comas Casanova P, Meijide Míguez H, Casas-Rojo JM, Gómez-Huelgas R, SEMI-COVID-19 Network. Cardiometabolic therapy and mortality in very old patients with diabetes hospitalized due to COVID-19. J Gerontol A Biol Sci Med Sci. Published online May 4, 2021. doi:10.1093/gerona/glab124
38. Ayala Gutiérrez MDM, Rubio-Rivas M, Romero Gómez C, Montero Sáez A, Pérez de Pedro I, Homs N, Ayuso García B, Cuenca Carvajal C, Arnalich Fernández F, Beato Pérez JL, Vargas Núñez JA, Letona Giménez L, Suárez Fernández C, Méndez Bailón M, Tuñón de Almeida C, González Moraleja J, de Guzmán García-Monge M, Helguera Amezua C, Fidalgo Montero MDP, Giner Galvañ V, Gil Sánchez R, Collado Sáenz J, Boixeda R, Ramos Rincón JM, Gómez Huelgas R, On Behalf Of The Semi-Covid-Network  null. Autoimmune Diseases and COVID-19 as Risk Factors for Poor Outcomes: Data on 13,940 Hospitalized Patients from the Spanish Nationwide SEMI-COVID-19 Registry. J Clin Med. 2021;10(9):1844. doi:10.3390/jcm10091844
39. Torres-Peña JD, Pérez-Belmonte LM, Fuentes-Jiménez F, López Carmona MD, Pérez-Martinez P, López-Miranda J, Carrasco Sánchez FJ, Vargas Núñez JA, del Corral Beamonte E, Magallanes Gamboa JO, González García A, González Moraleja J, Cortés Troncoso A, Taboada Martínez ML, del Fidalgo Montero M del P, Seguí Ripol JM, Gil Sánchez R, Alegre González D, Boixeda R, Cortés Rodríguez B, Ena J, García García GM, Ventura Esteve A, Ramos Rincón JM, Gómez-Huelgas R, Rojo JMC, Rincón JMR, Bermejo CL, Núñez-Cortés JM, Santos JMA, Huelgas RG, de Blas PA, Cañas CA, Ayuso B, Morejón JB, Escudero SC, Frías MC, Tejido SC, de Miguel Campo B, Pedroche CD, Simon RD, Reyne AG, Huerta LJ, Blanco AL, Gonzalo JL, Lora-Tamayo J, Bermejo CL, de la Calle GM, Perpiña BO, Ruiz DP, Fernández MS, Montes JT, Corbella X, Homs N, Montero A, Mora-Luján JM, Rivas MR, Casas LA, de Oña ÁA, Beato RA, Gonzalo LA, Muñoz JA, Oblitas CMA, García CA, Cebrián MB, Corral JB, Guerrero MB, Estrada AB, Moreno MC, Fernández PC, Carrillo R, Pérez SC, Muñoz EC, Moreno ADC, Carvajal MCC, de Santos S, Gómez AE, Carracedo EF, Jenaro MMFM, Valle FG, Garcia A, Fernandez-Bravo IG, Leoni MEG, Antunez MG, Narciso CGS, Gurjian AA, Ibáñez LJ, Olleros CL, Mendo CL, García SL, Jimeno VM, Nohales CM, Núñez-Cortés JM, Ledesma SM, Miguez AM, Delgado CM, Ortega LO, Sánchez SP, et al. Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry. Drugs. Published online March 29, 2021:1-11. doi:10.1007/s40265-021-01498-x
40. Lora-Tamayo J, Maestro G, Lalueza A, Rubio-Rivas M, Paul GV, Fernández FA, Pérez JLB, Núñez JAV, Barrio ML, Bermejo CL. Early Lopinavir/ritonavir does not reduce mortality in COVID-19 patients: results of a large multicenter study. Journal of Infection. 2021;0(0):S0163-4453(21)00077-3. doi:10.1016/j.jinf.2021.02.011
41. Artero A, Madrazo M, Fernández-Garcés M, Muiño Miguez A, González García A, Crestelo Vieitez A, García Guijarro E, Fonseca Aizpuru EM, García Gómez M, Areses Manrique M, Martinez Cilleros C, Fidalgo Moreno MDP, Loureiro Amigo J, Gil Sánchez R, Rabadán Pejenaute E, Abella Vázquez L, Cañizares Navarro R, Solís Marquínez MN, Carrasco Sánchez FJ, González Moraleja J, Montero Rivas L, Escobar Sevilla J, Martín Escalante MD, Gómez-Huelgas R, Ramos-Rincón JM. Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study. J Gen Intern Med. Published online February 11, 2021:1-8. doi:10.1007/s11606-021-06626-7
42. Antúnez MG, Míguez AM, Estrada ADB, Calle GM de la, Monge DM, Boixeda R, Ena J, Pérez CM, Santos JMA, Bermejo CL. Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2. Int J Chron Obstruct Pulmon Dis. 2021;15:3433-3445. doi:10.2147/COPD.S276692
43. Rubio-Rivas M, Corbella X, Formiga F, Menéndez Fernández E, Martín Escalante MD, Baños Fernández I, Arnalich Fernández F, Del Corral-Beamonte E, Lalueza A, Parra Virto A, Roy Vallejo E, Loureiro-Amigo J, Álvarez Suárez AM, Abadía-Otero J, Navarro De La Chica M, Estévez González R, Hernández Milián A, Areses Manrique M, Blázquez Encinar JC, González Noya A, González Ferrer R, Pérez Aguilera M, Gil Sánchez R, Millán Núñez-Cortés J, Casas-Rojo JM, on behalf of the SEMI-COVID-19 Network. Risk Categories in COVID-19 Based on Degrees of Inflammation: Data on More Than 17,000 Patients from the Spanish SEMI-COVID-19 Registry. J Clin Med. 2021;10(10):2214. doi:10.3390/jcm10102214
44. Josa-Laorden C, Crestelo-Vieitez A, García Andreu M del M, Rubio-Rivas M, Sánchez M, Toledo Samaniego N, Arnalich Fernández F, Iguaran Bermudez R, Fonseca Aizpuru EM, Vargas Núñez JA, Pesqueira Fontan PM, Serrano Ballesteros J, Freire Castro SJ, Pestaña Fernández M, Viana García A, Nuñez Rodriguez V, Giner-Galvañ V, Carrasco Sánchez FJ, Hernández Milián A, Cobos-Siles M, Napal Lecumberri JJ, Herrero García V, Pascual Pérez M de los R, Millán Núñez-Cortés J, Casas Rojo JM, for the SEMI-COVID-19 Network. Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study. Journal of Clinical Medicine. 2021;10(5):899. doi:10.3390/jcm10050899
45. Balaz D, Wikman-Jorgensen PE, Galvañ VG, Rubio-Rivas M, Campo B de M, López MN, Caleya JFL, Huelgas RG, Fontán PMP, Bailón MM, Fernández-Garcés M, Cruz AF, García GMG, Rhyman N, Corral-Gudino L, Rodríguez-Mancheño AL, Chica MNDL, García AT, Alcalá JN, Jiménez PD, Trallero LER, Casanova PC, Núñez-Cortés JM, Casas Rojo JM, SEMI-COVID-19 Network. Evolution of the Use of Corticosteroids for the Treatment of Hospitalised COVID-19 Patients in Spain between March and November 2020: SEMI-COVID National Registry. J Clin Med. 2021;10(19):4610. doi:10.3390/jcm10194610
46. Roy-Vallejo E, Sánchez Purificación A, Torres Peña JD, Sánchez Moreno B, Arnalich F, García Blanco MJ, López Miranda J, Romero-Cabrera JL, Herrero Gil CR, Bascunana J, Rubio-Rivas M, Pintos Otero S, Martínez Sempere V, Ballano Rodríguez-Solís J, Gil Sánchez R, Luque del Pino J, González Noya A, Navas-Alcántara MS, Cortés Rodríguez B, Alcalá JN, Suárez-Lombraña A, Andrés Soler J, Gómez-Huelgas R, Casas-Rojo JM, Millán Núñez-Cortés J, on behalf of the SEMI‐COVID‐19 Network  on. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Withdrawal Is Associated with Higher Mortality in Hospitalized Patients with COVID-19. Journal of Clinical Medicine. 2021;10(12). doi:10.3390/jcm10122642
47. Mateos González M, Sierra Gonzalo E, Casado Lopez I, Arnalich Fernández F, Beato Pérez JL, Monge Monge D, Vargas Núñez JA, García Fenoll R, Suárez Fernández C, Freire Castro SJ, Mendez Bailon M, Perales Fraile I, Madrazo M, Pesqueira Fontan PM, Magallanes Gamboa JO, González García A, Crestelo Vieitez A, Fonseca Aizpuru EM, Aranguren Arostegui A, Coduras Erdozain A, Martinez Cilleros C, Loureiro Amigo J, Epelde F, Lumbreras Bermejo C, Antón Santos JM, Network  for the SC 19. The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals. Journal of Clinical Medicine. 2021;10(2):305. doi:10.3390/jcm10020305
48. Díez-Manglano J, Solís-Marquínez MN, Álvarez García A, Alcalá-Rivera N, Maderuelo Riesco I, Gericó Aseguinolaza M, Beato Pérez JL, Méndez Bailón M, Labirua-Iturburu Ruiz AE, García Gómez M, Martínez Cilleros C, Pesqueira Fontan PM, Abella Vázquez L, Blázquez Encinar JC, Boixeda R, Gil Sánchez R, de la Peña Fernández A, Loureiro Amigo J, Escobar Sevilla J, Guzmán Garcia M, Martín Escalante MD, Magallanes Gamboa JO, Martínez González ÁL, Lumbreras Bermejo C, Antón Santos JM. Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry. PLoS One. 2021;16(2):e0247422. doi:10.1371/journal.pone.0247422
49. Rodilla E, Lopez-Carmona MD, Cortes X, Cobos-Palacios L, Canales S, Saez MC, Campos-Escudero S, Rubio-Rivas M, Diez-Manglano J, Freire-Castro SJ, Vazquez-Piqueras N, Mateo-Sanchis E, Pesqueira-Fontan PM, Magallanes-Gamboa JO, Gonzalez-Garcia A, Madrid-Romero V, Tamargo-Chamorro L, Gonzalez Moraleja J, Villanueva-Martinez J, Gonzalez-Noya A, Suárez-Lombraña A, Gracia-Gutierrez A, Lopez Reboiro ML, Ramos-Rincon JM, Gomez-Huelgas R. Impact of arterial stiffness on all-cause mortality in patients hospitalized with COVID-19 in Spain. Hypertension. 2020;77(3):856-867. doi:10.1161/HYPERTENSIONAHA.120.16563
50. Pérez-Belmonte LM, Torres-Peña JD, López-Carmona MD, Ayala-Gutiérrez MM, Fuentes-Jiménez F, Huerta LJ, Muñoz JA, Rubio-Rivas M, Madrazo M, Garcia MG, Montes BV, Sola JF, Ena J, Ferrer RG, Pérez CM, Ripper CJ, Lecumberri JJN, Acedo IEA, Canteli SP, Cosío SF, Martínez FA, Rodríguez BC, Pérez-Martínez P, Ramos-Rincón JM, Gómez-Huelgas R. Mortality and other adverse outcomes in patients with type 2 diabetes mellitus  admitted for COVID-19 in association with glucose-lowering drugs: a nationwide  cohort study. BMC Med. 2020;18(1):359. doi:10.1186/s12916-020-01832-2
51. Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, Lumbreras-Bermejo C, Ramos-Rincón JM, Roy-Vallejo E, Artero-Mora A, Arnalich-Fernández F, García-Bruñén JM, Vargas-Núñez JA, Freire-Castro SJ, Manzano-Espinosa L, Perales-Fraile I, Crestelo-Viéitez A, Puchades-Gimeno F, Rodilla-Sala E, Solís-Marquínez MN, Bonet-Tur D, Fidalgo-Moreno MP, Fonseca-Aizpuru EM, Carrasco-Sánchez FJ, Rabadán-Pejenaute E, Rubio-Rivas M, Torres-Peña JD, Gómez-Huelgas R. Clinical characteristics of patients hospitalized with COVID-19 in Spain: Results  from the SEMI-COVID-19 Registry. Rev Clin Esp. 2020;220(8):480-494. doi:10.1016/j.rceng.2020.07.003
52. Rubio-Rivas M, Corbella X, Mora-Luján JM, Loureiro-Amigo J, López Sampalo A, Yera Bergua C, Esteve Atiénzar PJ, Díez García LF, Gonzalez Ferrer R, Plaza Canteli S, Pérez Piñeiro A, Cortés Rodríguez B, Jorquer Vidal L, Pérez Catalán I, León Téllez M, Martín Oterino JÁ, Martín González MC, Serrano Carrillo de Albornoz JL, García Sardon E, Alcalá Pedrajas JN, Martin-Urda Diez-Canseco A, Esteban Giner MJ, Tellería Gómez P, Ramos-Rincón JM, Gómez-Huelgas R. Predicting Clinical Outcome with Phenotypic Clusters in COVID-19 Pneumonia: An  Analysis of 12,066 Hospitalized Patients from the Spanish Registry SEMI-COVID-19. J Clin Med. 2020;9(11):3488. doi:10.3390/jcm9113488
53. Ramos-Rincon JM, Buonaiuto V, Ricci M, Martín-Carmona J, Paredes-Ruíz D, Calderón-Moreno M, Rubio-Rivas M, Beato-Pérez JL, Arnalich-Fernández F, Monge-Monge D, Vargas-Núñez JA, Acebes-Repiso G, Mendez-Bailon M, Perales-Fraile I, García-García GM, Guisado-Vasco P, Abdelhady-Kishta A, Pascual-Pérez M de LR, Rodríguez-Fernández-Viagas C, Montaño-Martínez A, López-Ruiz A, Gonzalez-Juarez MJ, Pérez-García C, Casas-Rojo JM, Gómez-Huelgas R. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients  Hospitalized with COVID-19 in Spain. J Gerontol A Biol Sci Med Sci. 2020;76(3):e28-e37. doi:10.1093/gerona/glaa243
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Cartas al director

1. Salinas-Botrán A, Pérez-Belmonte LM, Méndez-Bailón M. Respuesta a la carta Tratamiento con glucocorticoides en pacientes con COVID-19 e insuficiencia cardíaca concurrente. Revista Clínica Española. Published online November 20, 2021. doi:10.1016/j.rce.2021.11.001
2. Pérez-Belmonte LM, Sanz-Cánovas J, Salinas A, Fornie IS, Méndez-Bailón M, Gómez-Huelgas R, the SEMI-COVID-19 Network. Corticosteroid therapy in patients with heart failure hospitalized for COVID-19: a multicenter retrospective study. Intern Emerg Med. Published online October 12, 2021. doi:10.1007/s11739-021-02843-4
3. Luis M. Pérez-Belmonte, Jaime Sanz-Cánovas, Alejandro Salinas, Jose Luis Garcia-Klepzig, Manuel Méndez-Bailón, Ricardo Gómez-Huelgas. Adverse outcomes in patients with heart failure admitted for COVID-19 in association with renin-angiotensin-aldosterone system inhibitors. Polish Archives of Internal Medicine. Published online October 2021. doi:10.20452/pamw.16126
4. Loureiro-Amigo J, Suárez-Carantoña C, Oriol-Bermúdez I, Sánchez-Díaz C, Coloma-Conde A, Manzano-Espinosa L, Rubio-Rivas M, Otero-Perpiñá B, Jenaro MMFM, Coduras-Erdozain A, Garcia-Klepzig JL, Vargas-Parra D, Pesqueira-Fontán PM, Fiteni-Mera I, García-García GM, Jiménez-Torres J, Rodríguez-Cortés P, Costo-Muriel C, Arnalich-Fernández F, Artero A, Carrasco-Sánchez FJ, Escobar-Sevilla J, Alcalá-Pedrajas JN, Gómez-Huelgas R, Ramos-Rincón JM. Prone Position in COVID-19 Patients With Severe Acute Respiratory Distress Syndrome Receiving Conventional Oxygen Therapy: A Retrospective Study. Archivos de Bronconeumología. Published online June 6, 2021. doi:10.1016/j.arbres.2021.05.018
5. Martos Pérez F, Gomez Huelgas R, Martín Escalante MD, Casas Rojo JM. Minimizing Selection and Classification Biases. Comment on “Clinical Characteristics and Prognostic Factors for Intensive Care Unit Admission of Patients With COVID-19: Retrospective Study Using Machine Learning and Natural Language Processing.” J Med Internet Res. Published online May 13, 2021. doi:10.2196/27142
6. Bernabeu-Wittel M, Gómez-Huelgas R, Nieto-Martín MD. Time to Stop the Tragedy in Spanish Nursing Homes during the COVID-19 Pandemic. J Am Geriatr Soc. 2020;69(2):320-322. doi:10.1111/jgs.16943